The majority of the city lies within Fort Bend County, while a small section is situated in Harris County. According to the 2020 census, the city’s population was 74,259, showing growth from the 2010 count of 67,358.
In 1996, certain areas within Missouri City and Houston share postal addresses, despite being under different municipal jurisdictions. This anomaly arises from the fact that the U.S. postal system does not align its mailing addresses with city limits.